Sildenafil (Revatio ) – Pulmonary Hypertension Association

Aims: Pulmonary hypertension (PH) is a severe and prevalent complication of chronic obstructive pulmonary disease (COPD), with low quality of life and poor prognosis. This study was designed to evaluate the efficacy and safety of Sildenafil in the treatment of PH caused by COPD (COPD-PH) and provide reference for clinical treatment. All sildenafil doses reduced the mean pulmonary-artery pressure (P=0.04, P=0.01, and P 0.001, respectively), improved the WHO functional class (P=0.003, P 0.001, and P 0.001 Sildenafil is a phosphodiesterase type 5 inhibitor that has an expanding role in the treatment of pulmonary hypertension. Case series and small studies, as well as the first large randomized controlled trial, have demonstrated the safety and efficacy of sildenafil in improving mean pulmonary artery pressure, pulmonary vascular resistance Sildenafil is an oral medication called a phosphodiesterase-5 (PDE5) inhibitor approved for the treatment of pulmonary arterial hypertension (PAH) in World Health Organization (WHO) Group 1 patients. The goal of this therapy is to improve exercise ability and delay clinical worsening. sildenafil for pulmonary hypertension guidelines This study assessed whether lower doses were less effective than the approved 20-mg TID dosage. Treatment-naive patients with pulmonary arterial hypertension were randomized

4. Chronic thromboembolic pulmonary hypertension and other pulmonary artery obstructions 4.1 Chronic thromboembolic pulmonary hypertension 4.2 Other pulmonary artery obstructions 5. Pulmonary hypertension with unclear and/or multifactorial mechanisms 5.1 Haematological disorders 5.2 Systemic disorders 5.3 Metabolic disorders 5.4 Others Significance: Available clinical evidence indicates that Sildenafil seems to be safe and effective for COPD-PH and can improve the patients’ 6WMD. However, large-sample, high-quality multicenter RCTs are still needed to provide stronger evidence-based medical evidence. Sprecher VP, Didden EM, Swerdel JN, Muller A. Evaluation of code-based algorithms to identify pulmonary arterial hypertension and chronic thromboembolic pulmonary

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